- Case Report
- Immunology
- Familial Mediterranean fever presenting as fever of unknown origin in Korea
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Jun Hee Lee, Jong Hyun Kim, Jung Ok Shim, Kwang Chul Lee, Joo Won Lee, Jung Hwa Lee, Jae Jin Chae
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Clin Exp Pediatr. 2016;59(Suppl 1):S53-S56. Published online November 30, 2016
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Familial Mediterranean fever (FMF) is the most common Mendelian autoinflammatory disease, characterized by uncontrolled activation of the innate immune system that manifests as recurrent brief fever and polyserositis (e.g., peritonitis, pleuritic, and arthritis). FMF is caused by autosomal recessive mutations of the Mediterranean fever gene, MEFV which encodes the pyrin protein. Although FMF predominantly affects people from Mediterranean and Middle... |
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- Original Article
- Cardiology
- Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus
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Hyun Ah Jeong, Jeonghee Shin, Eunji Kim, Eun Hee Lee, Byung Min Choi, Chang Sung Son, Joo Won Lee
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Clin Exp Pediatr. 2016;59(4):183-189. Published online April 30, 2016
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Purpose This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress. MethodsWe enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels... |
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- Nephrology (Genitourinary)
- Impaired angiogenesis in the enalapril-treated neonatal rat kidney
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Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016
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Purpose Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney. MethodsNewborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular... |
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- Effect of angiotensin II inhibition on the epithelial to
mesenchymal transition in developing rat kidney
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Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2009;52(8):944-952. Published online August 15, 2009
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Purpose:To investigate the effects of angiotensin II inhibition on the epithelial to mesenchymal transition (EMT) in the developing
kidney, we tested the expression of EMT markers and nestin in angiotensin converting enzyme (ACE) inhibitor-treated
kidneys.
Methods:Newborn rat pups were treated with enalapril (30 mg/kg/d) or a vehicle for 7 days. Immunohistochemistry for the
expression of α-smooth muscle actin (SMA), E-cadherin, vimentin, and nestin were... |
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- Functional recovery after transplantation of mouse bone marrow-derived
mesenchymal stem cells for hypoxic-ischemic brain injury in immature rats
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Wooksun Choi, Hye Kyung Shin, So-Hee Eun, Hoon Chul Kang, Sung Won Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Baik-Lin Eun
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Clin Exp Pediatr. 2009;52(7):824-831. Published online July 15, 2009
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Purpose : We aimed to investigate the efficacy of and functional recovery after intracerebral transplantation of different doses of mouse mesenchymal stem cells (mMSCs) in immature rat brain with hypoxic-ischemic encephalopathy (HIE).
Methods : Postnatal 7-days-old Sprague-Dawley rats, which had undergone unilateral HI operation, were given stereotaxic intracerebral injections of either vehicle or mMSCs and then tested for locomotory activity in... |
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- Case Report
- Two cases of Smith-Magenis syndrome
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Seong Kwan Jung, Kyu Hee Park, Hae Kyung Shin, So Hee Eun, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Sook Young Bae
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Clin Exp Pediatr. 2009;52(6):701-704. Published online June 15, 2009
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SmithMagenis syndrome (SMS) is a rare disorder with multiple congenital anomalies caused by a heterozygous interstitial deletion involving chromosome 17p11.2, where the retinoic acid-induced 1 (RAI1) gene is located, or by a mutation of RAI1. Approximately 90% of the patients with SMS have a detectable 17p11.2 microdeletion on fluorescence in-situ hybridization (FISH). SMS is characterized by mental retardation, distinctive behavioral... |
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- Original Article
- Evaluating and managing hypertension in children: a survey of Korean cardiologists and nephrologists
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Eun Hee Lee, Hyung Eun Yim, Gi Young Jang, Kee Hwan Yoo, Chang Sung Son, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2008;51(9):992-997. Published online September 15, 2008
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Purpose : Hypertension (HTN) is no longer an exclusively adult disease; the prevalence of pediatric HTN is increasing. To understand the evaluation and treatment of childhood HTN in Korea, we investigated, via a questionnaire, how hypertensive children are currently assessed and managed by pediatric cardiologists (CA) and nephrologists (NE).
Methods : We surveyed 82 pediatric CA and 77 NE, regarding... |
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- Complications of transcatheter closure of atrial septal defects
using the amplatzer septal occluder
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Seo Jin Jea, Hyo Jin Kwon, Gi Young Jang, Jae Young Lee, Soo Jin Kim, Chang Sung Son, Joo Won Lee
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Clin Exp Pediatr. 2008;51(4):401-408. Published online April 15, 2008
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Purpose : Transcatheter closure of atrial septal defects (ASD) is currently established therapy as an alternative to surgery. But rarely, complications are reported in some studies. We report early and intermediate term complications associated with transcatheter closure of atrial septal defects using the Amplatzer septal occluder (ASO).
Methods : From June 2003 to May 2006, 64 patients underwent transcatheter closure of... |
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- Use of herbal medicine in epileptic children
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Jee Yeon Lee, Wook Sun Choi, So-Hee Eun, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2008;51(4):415-419. Published online April 15, 2008
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Purpose : Herbal medicine is thought to be widely used by children with epilepsy, but there have been few studies. This study aimed to investigate the perceptions and the actual conditions of usage of herbal medicine by children with epilepsy.
Methods : From July to August 2007, three hundred seventy eight questionnaires were completed by parents of epileptic children who visited... |
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- Efficacy and safety of oxcarbazepine in epileptic children
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Hye Kyung Shin, Yoon Lee, Jee-Yeon Lee, Wooksun Choi, So-Hee Eun, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2008;51(2):162-169. Published online February 15, 2008
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Purpose : Oxcabarzepine (OXC), newly recommended antiepileptic drug, has been prescribed for patients with partial seizures and generalized tonic clonic seizures in Korea from 1999. There are limited reports about an efficacy of OXC therapy in epileptic children in Korea. This study evaluated the efficacy and safety of OXC in the light of our experience.
Methods : The patients, who had... |
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- Usefulness of video-EEG monitoring in paroxysmal nonepileptic
events of children and adolescents
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Jee Yeon Lee, Hee Sun Lee, Wook Sun Choi, So Hee Eun, Ki Hyung Lee, Baik Lin Eun, Joo Won Lee
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Clin Exp Pediatr. 2008;51(1):62-66. Published online January 15, 2008
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Purpose : This study was designed to clarify the mechanism of proteinuria in nephrotic syndrome patients by using puromycin aminonucleoside (PAN) nephrosis model.
Methods : Following administration of various concentrations of PAN and antioxidants we observed the changes of podocyte cytoskeletons in cultured rat glomerular epithelial cells (GEpC) by method of scanning electron microscope, reactive oxyten species (ROS) analysis, permeability assay,... |
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- Alteration of insulin resistance and serum adiponectin levels after one year follow-up of obese children and adolescents
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Min Jee Jeoung, Jung Yeon Shin, Soo Young Kim, Jung Hwa Lee, Kee-Hyoung Lee, Joo Won Lee
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Clin Exp Pediatr. 2007;50(8):767-773. Published online August 15, 2007
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Purpose : Obesity has become a pandemic and especially the prevalence of childhood obesity has increased remarkably over the past years. Childhood obesity is often accompanied by the expected morbidities such as hyperlipidemia, fatty liver and glucose intolerance. We evaluated the pattern of alteration in the body mass index (BMI), serum adiponectin concentration, insulin resistance (HOMA-IR), and complication rates after... |
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- Clinical application of D-dimer in Kawasaki Disease
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Jae Joon Han, Hong Ki Ko, Young Yoo, JungHwa Lee, Kwang Chul Lee, Chang Sung Son, Joo Won Lee
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Clin Exp Pediatr. 2007;50(2):205-208. Published online February 15, 2007
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Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
Purpose : Vascular endothelial cell damage and alteration of a fibrinolytic system was suggested to play a role in the development of coronary artery abnormalities in Kawasaki disease (KD). D-dimer is one of the markers of endothelial damage and fibrinolysis. We evaluated the clinical usefulness of D- dimer to differentiate KD... |
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- Carotid artery intima media thickness in obese children :
relation with cardiovascular risk factors
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Jin Lee, Hyo Jin Kwon, Moon Ho Park, Ki Young Jang, Kee-Hyoung Lee, Kwang Chul Lee, Chang Sung Son, Joo Won Lee
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Clin Exp Pediatr. 2007;50(11):1091-1096. Published online November 15, 2007
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Purpose : The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors.
Methods : We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood... |
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- Case Report
- Primary peritoneal drainage as a treatment for perforated necrotizing enterocolitis with bacterial peritonitis in an extremely low birth weight infant : a case report
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Wook Sun Choi, Il Hong Moon, Jang Hoon Lee, Seung Hwa Lee, Byung Min Choi, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2006;49(7):800-804. Published online July 15, 2006
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Necrotizing enterocolitis(NEC) is the most common life-threatening surgical emergency in neonates, and remains a major cause of morbidity and mortality. In addition to conventional laparotomy, intraperitoneal drains have been used for the treatment of perforated NEC, especially in extremely low birth weight(ELBW) infants. We report a case of perforated NEC with bacterial peritonitis in an ELBW infant managed with primary... |
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- Original Article
- The auditory evoked potential in premature small for gestational age infants
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Il Hong Moon, Kee Soo Ha, Gui Sang Kim, Byung Min Choi, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2006;49(12):1308-1314. Published online December 15, 2006
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Purpose : This study aimed to evaluate the usefulness of auditory evoked potential (AEP) in clarifying neuronal development in premature small for gestational age (SGA), and appropriate for gestational age (AGA) infants.
Methods : A total of 183 premature infants who were born from August 2002 to July 2005, were examined with AEP. They were divided into three groups; AGA, symmetric-SGA... |
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- The effects of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants
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Wooksun Choi, Jung-Yeon Shin, Byung Min Choi, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2006;49(12):1315-1323. Published online December 15, 2006
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Purpose : This study was conducted to compare the efficacy and safety of ibuprofen and indomethacin in the treatment of patent ductus arteriosus (PDA) in preterm infants and to determine whether ibuprofen can be an alternative drug.
Methods : A total of 32 preterm infants with symptomatic PDA were enrolled in the study. Twelve infants received intravenous ibuprofen 10 mg/kg, followed... |
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- Usefulness of modified ambu in patients who need artificial ventilation
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Kee Soo Ha, Il Hong Moon, Hee Sun Lee, Dong Han Shin, So Hee Eun, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2006;49(11):1194-1201. Published online November 15, 2006
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Purpose : The comatose mentality can be catastrophic, especially if the condition is severe or the duration is prolonged. Therefore, delayed diagnosis can result in a poor outcome or death. The best radiologic modality to differentiate from cerebral lesions in patients suffering from cerebral diseases is magnetic resonance imaging (MRI) rather than computed tomography (CT). Special apparatuses with metal... |
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- Usefulness of Korean Infant Developmental Screening Test in Premature Infants
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Dong Han Shin, Hee Sun Lee, Jee Yeon Lee, Byung Min Choi, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2005;48(12):1337-1341. Published online December 15, 2005
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Purpose : This study aimed to evaluate the usefulness of Korean Infant Development Screening Test in predicting delayed development in premature infants.
Methods : A total of 74 children with histories of prematurity, who visited the pediatric neurology clinic of Korean University Ansan Hospital from August, 2002 to July, 2004, were examined, using the Korean Infant Development Screening Test. They were... |
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- Case Report
- A Case of Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Presenting as Uric Acid Lithiasis
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Ji Hae Kim, Mi Jung Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2004;47(9):1020-1023. Published online September 15, 2004
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The deficiency of enzyme hypoxanthine-guanine phosphoribosyltransferase(HPRT) results in hyperuricemia and subsequently manifests in diverse symptoms. Lesch-Nyhan syndrome is a disorder characterized by hyperuricemia, mental retardation, choreoathetosis, spasticity and self-mutilation, resulting from complete deficiency of the enzyme, whereas partial deficiency of the enzyme shows symptoms of milder forms more often without abnormal neurologic signs. A 7-year-old boy with normal growth and... |
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- Original Article
- A Multivariate Analysis of Risk Factors of Renal Involvement in Henoch-Sch nlein Purpura
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Min Jee Jeoung, Hyung Eun Yim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2004;47(4):405-411. Published online April 15, 2004
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Purpose : Long-term prognosis of Henoch-Sch nlein purpura(HSP) is determined by the existence and severity of renal involvement. We evaluated the relationship between various clinical features of HSP and the development of renal involvement using univariate and multivariate analyses for early detection and proper management of HSP nephritis.
Methods : We performed a retrospective study of 200 children who were diagnosed... |
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- Risk Factors for the First-Year Relapse in
Children with Nephrotic Syndrome
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Hye Kyoung Shin, Ji Hee Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2003;46(9):889-892. Published online September 15, 2003
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Purpose : This study aimed to evaluate risk factors of the first year relapse in children with nephrotic syndrome(NS) without the need for biopsy.
Methods : We reviewed, retrospectively, 78 children diagnosed with steroid responsive nephrotic syndrome between July 1997 and June 2002. Median years to follow up were 4.4 years(range : 1-5 years). We divided the patients into two groups(group... |
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- Case Report
- A Case of Intestinal Lymphangiectasia
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Hyung Eun Yim, Min Ji Jung, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2003;46(9):921-925. Published online September 15, 2003
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Intestinal lymphangiectasia, one of the protein-losing gastroenteropathies, is an uncommon disease characterized by dilated intestinal lymphatics, enteric protein loss, edema, hypoalbuminemia, and lympocytopenia. Small bowel biopsy and CT have been used to confirm the diagnosis of intestinal lymphangiectasia. Small bowel biopsy shows collections of abnormal dilated lacteals in submucosa with distortion of villi and CT findings have been described as... |
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- Original Article
- Effects of Endothelin A Receptor Antagonist to Cellular Proliferation and Apoptosis in Neonatal Rat Heart
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Byung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2003;46(7):668-678. Published online July 15, 2003
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Purpose : In order to investigate the role of endothelins in the cardiac development, the present study was designed to examine the effects of endothelin A receptor(ETAR) antagonist to the cellular proliferation and apoptosis in the neonatal rat heart. In addition, the expression of various regulatory genes in protein and mRNA levels by ETAR antagonist were examined.
Methods : Neonatal... |
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- Recurrence and Follow-up after Urinary Tract Infection
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Ji Hee Kim, Hye Kyung Shin, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2003;46(6):561-565. Published online June 15, 2003
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Purpose : Urinary tract infection(UTI) is the most common bacterial infectious disease that may induce severe renal injury unless early diagnosis and appropriate treatment are performed. If recurrent UTI is prevented, renal injury can be also reduced. Therefore, we studied the risk factors of recurrent UTI in children.
Methods : We performed a retrospective study of 168 children(58 girls and 110... |
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- The Role of Aldosterone on the Development of Renal
Tubular Reabsorption in Low Birth Weight Infants
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Byung Min Choi, Hoe Kyoung Koo, Jin Won Yook, Kyoung Bum Kim, Gi Young Jang, Moon Hee Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2001;44(11):1233-1242. Published online November 15, 2001
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Purpose : To determine the postnatal changes in aldosterone action on the renal tubular reabsorption in low birth weight(LBW) infants, we assessed the relation of the aldosterone concentrations to renal parameters during the first 10 days of life.
Methods : Twenty LBW infants were evaluated and their gestational ages ranged from 32.4 to 39.3 weeks and their birth weights ranged from... |
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- Evoked Potentials and Cranial Ultrasonography as a
Prognostic Method in Newborn with Asphyxia
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Hyung Jin Kim, Hee Kang, Byoung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2001;44(10):1162-1167. Published online October 15, 2001
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Purpose : This study was aimed at finding a diagnostic tool which is useful in predicting the neurologic outcome of the asphyxiated newborns.
Methods : 31 newborns with asphyxia were evaluated by brainstem evoked potentials and cranial ultrasonography(CUS). During the neonatal follow-up, we evaluated the development of the babies with Bayley Scale of Infant Development II and INFANIB on corrected age... |
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- Postnatal Changes in Left Ventricular Performance in Early Neonatal Life
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Sung Wook Yang, Chan Wook Woo, Jee Youn Lim, Jung Hwa Lee, Joo Won Lee, Chang Sung Son, Young Chang Tockgo, Young Yoo
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Clin Exp Pediatr. 2000;43(9):1168-1173. Published online September 15, 2000
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Purpose : This study was undertaken to investigate changes in cardiac performance in early neonatal life by observing the changes of left ventricular(LV) function and volume according to the size of ductus arteriosus.
Methods : The study group consisted of 21 full-term Cesarean section neonates who were admitted to the nursery of Korea University Hospital. We serially investigated the... |
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- Usefulness of Plasma Atrial Natriuretic Peptide Concentration in the Diagnosis of Patent Ductus Arteriosus in Preterm Infants
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Byung Min Choi, Jae Kyun Yoon, Hyun Hee Lee, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2000;43(7):897-904. Published online July 15, 2000
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Purpose : Diagnosis of a hemodynamically significant patent ductus arteriosus(PDA) that should
be treated is difficult to determine by clinical and echocardiographic examinations. The aim of this
study was to clarify the interrelationship of plasma atrial natriuretic peptide(ANP) concentrations
and clinical signs or echocardiographic signs of PDA in preterm infants and use plasma ANP
concentrations as a diagnostic indicator of a hemodynamically significant PDA.
Methods... |
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- Case Report
- A Case of Factor Ⅶ Deficiency Presenting as Hemarthroses
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Han Seong Ko, Kee Hwan Yoo, Kwang Chul Lee, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2000;43(3):428-431. Published online March 15, 2000
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Factor Ⅶ deficiency has an estimated incidence of 1/500,000 in the general population and autosomal recessive pattern of inheritance. Factor Ⅶ deficiency is characterized by prolonged prothrombin time(PT), and normal activated partial thromboplastin time(aPTT) and bleeding time(BT). Definite diagnosis of this condition requires a specific Factor Ⅶ assay. The clinical features are variable and do not always correlate with the... |
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- Original Article
- Effects of Angiotensin Converting Enzyme Inhibition into Apoptosis and Related Genes in the Neonatal Rat Kidney
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Kee Hwan Yoo, Haewon Cheon, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1999;42(8):1086-1095. Published online August 15, 1999
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Purpose : The renin-angiotensin system plays an important role in renal growth and development. Exposuring the neonate to angiotensin converting enzyme(ACE) inhibitor increases mortality and results in growth retardation and abnormal renal development. ACE inhibition in the developing kidney reduces the renal expression of TGF-β1 and EGF, which may account for renal growth impairment. This study was designed to... |
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- Clinical Efficiency of Cardiac Troponin T for Myocardial Damage in Neonatal Asphyxia
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Nam Soo Kang, Jae Kyun Yoon, Chang Sung Son, Joo Won Lee, Young Chang Tokgo, Sang Hee Kim
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Clin Exp Pediatr. 1999;42(2):195-202. Published online February 15, 1999
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Purpose : The aim of this study was to evaluate the clinical efficiency of cardiac troponin T (cTnT) in detecting myocardial damage in neonatal asphyxia and to compare the diagnostic value of cTnT with creatine kinase MB(CK-MB).
Methods : Sixty-three neonates were enrolled in this study, consisting of 27 asphyxiated infants (asphyxiated group; 1-min or 5-min Apgar score≤6) and 36 healthy... |
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- Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
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Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1998;41(9):1188-1197. Published online September 15, 1998
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Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors.
Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one... |
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- Thyroid Function Studies in Patients Who Underwent Open Heart Surgery
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Hyung Joo Sohn, Yu In Park, Chang Sung Son, Joo Won Lee, Young Chang Tockg
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Clin Exp Pediatr. 1998;41(9):1250-1255. Published online September 15, 1998
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Purpose : Alteration in the serum level of thyroid hormone can occur following open heart surgery due to major stress and hemodilution after extracorporeal circulation but these changes have been ignored. The purpose of this study is to evaluate the changes of thyroid hormone level after open heart surgery and if these changes influence the prognosis.
Methods : We evaluated 26... |
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- Study of a Comparison of Ultrasonography with Radiography to Localize the Umbilical Arterial Catheter
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Byoung Min Choi, Young Kwan Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1998;41(12):1650-1659. Published online December 15, 1998
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Purpose : This study was performed to observe the utilization of ultrasonography in locating the position of UAC and to compare the position with anatomical landmarks seen on radiography.
Methods : Optimal position is when the catheter tip is located between T6-T10 or L3-L5 by anteroposterior radiography(AP-R) and above the diaphragm by cross-table lateral radiography(CTL-R). Ultrasonographic studies used a Hewlett Packard... |
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- The Effect of Steroid Therapy on Growth and Bone Density in Children with Nephrotic Syndrome
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Seong Hoi Jeon, Ae Yeon Lim, Young Kook Kim, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1998;41(10):1396-1402. Published online October 15, 1998
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Purpose : Long-term steroid therapy for various glomerular disorders in children has been known to decrease serum Vit D3 level and develop osteomalacia. The aim of this study was to observe the effect of long-term steroid therapy on growth and bone density in children with nephrotic syndrome.
Methods : Bone density of 17 steroid-treated nephrotic syndrome was compared with that of... |
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- A Study of Tubular Fluid Effects to Dysmorphic Urinary RBCs in Glomerular Hematuria
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Byung Min Choi, Hyun Joo Kwak, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1996;39(4):512-521. Published online April 15, 1996
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Purpose : Urinary red blood cell morphology has been used to localize the site of hematuria in the urinary tract. But the pathologic mechanism for dysmorphic urinary red blood cells remains undefIned.
Our study was undertaken to investigate the mechanism of dysmorphic urinary RBCs in
glomerular hematuria. We have attempted to reproduce in vitro the changes that occur in red cell... |
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- The Effect of ACTH on Mouse Heart
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Sang Young Seo, Joo Won Lee, Chang Sung Son, Young Chang Tockgo
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Clin Exp Pediatr. 1995;38(6):804-810. Published online June 15, 1995
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Purpose : Adrenocorticotropic Hormone(ACTH) therapy is useful in the treatment of patients with infantile spasm. However, serious side effects including Cushing syndrome, infections, hypertension, and electrolyte imbalance must be encountered. Moreover, hypertrophic cardiomyopathy in association with ACTH therapy has recently reported. We performed thiw study to evaluate the effect of ACTH on heart muscle.
Methods : We administered ACTH subcutaneously to... |
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- A Study of Bone Marrow Density in Korean Children of Normal Growth and Development
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Byung Yoen Kim, Young Guk Kim, Young Jun Kim, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1995;38(5):612-618. Published online May 15, 1995
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Bone mineral densitometry is a useful procedure for the early detection of metabolic bone diseases and bone density changes caused by long term drug use. Dual energy X-ray absorpt- iometry(DEXA), a recently developed diagnostic radiologic method for evaluating bone mineral density is widely used because of its high sensitivity, easily obtaine results. and low dose radi- ation exposure. The study... |
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- Serum Lipids in Children and Adolescents with Family History of Coronary Artery Diseases
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Kee Hyoung Lee, Chang Sung Son, Joo Won Lee, young
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Clin Exp Pediatr. 1995;38(4):482-492. Published online April 15, 1995
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Purpose : Atherosclerotic change begins in childhood, elevated blood lipid levels and a family history of premature coronary vascular diseases are important risk factors for coronary artery disease. Identification, follow-up and treatment of children at high risk of cardiovascular diseases are very effective and important for prevention of future coronary artery diseases. The purpose of this study is to determine... |
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- Doppler Analysis of Renal Blood Flow in Normal Children
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Hyun Joo Kwak, Jae Yong Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 1995;38(3):328-338. Published online March 15, 1995
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Purpose : Recent development in ultrasonic Doppler instrumentation have allowed the direct noninvasive assessment of human renal artery blood flow. The authors conducted this study to assess noninvasive characterization of normal renal artery blood flow variables hopping to establish standards in normal children.
Methods : A total 97 normal Subjects(below the age 3 years) were examinated using by 2-D and... |
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- Case Report
- A Case of Miescher Syndrome with Insulin-Resistant Diabetes Mellitus
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Byung Min Choi, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1994;37(9):1292-1295. Published online September 15, 1994
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Miescher syndrome comprises congenital acanthosis nigricans, hypertrichosis, failure to thrive and short stature, dysmorphism especially of the jaws and oral cavity. Insulin-resistant diabetes mellitus, and a characteristic general appearance.
This report concerns a rare case of 12-year-old girl having insulin resistant diabetic mellitus with Miescher syndrome.
The relevant literature was reviewed. |
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- Original Article
- The Metabolic Acidosis and Clinical Outcome in Acute Infantile Diarrhea
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Ae Yeon Lim, Yo Ahn Rho, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1994;37(3):332-338. Published online March 15, 1994
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To determine the types of metabolic acidosis using anion gap in acute infantile diarrhea and to correlate it with clinical outcome, we examined 103 infants admitted with acute diarrhea. The serum electrolytes (sodium, potassium, chloride, phosphorus), creatinine, CO2 content and anion gap were measured on first admission day. They were classified group A with normal anion gap (8~16 mEq/L) and... |
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- The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
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Yoon Suck Suh, Young Guk Kim, Jung Hwa Lee, Kee Hwan Yoo, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1994;37(3):368-375. Published online March 15, 1994
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The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5 female, dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children... |
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- Case Report
- A Case of Type V Hyperlipoproteinemia
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Yo Ahn Rho, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1994;37(12):1752-1756. Published online December 15, 1994
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The hyperlipoproteinemias are the disturbance of lipid transport resulted from accelerated synthesis or retarded degradation of lipoproteins that transport cholesterol and trigycerides through plasma.
These diseases are classified as type I, type IIa, type IIb, type III, type IV, type V, and hyper-α-triglyceride levels due to increases in both VLDL and chylomicrons and lipoprotein electrophoresis shows increases pre-β, β, and... |
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- Original Article
- EEG Abnormalities in Henoch-Schölein Purpura
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Hae Wom Cheon, Dong Gun Park, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1994;37(11):1600-1606. Published online November 15, 1994
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Schölein-Henoch purpura is a generalized small vessel vasculitis characterized by non-thrombocytopenic purpura, arthritis, abdominal pain and nephritis. In 1913 Osler described an allergic purpura associated with hemiplegia. After then Lewis et al. Reported the cases of Schölein-Henoch purpura associated with convulsion, coma, confusion, intracranial hemorrhage, and chorea, CNS complication has been reported in 1-8% of children and subsided spontaneously in... |
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- A Clinical Survey of Prolonged Q-T Syndrome among Korean Children with Congenital Deafness
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Kang Woo Lee, Kyung Bum Kim, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1993;36(9):1236-1244. Published online September 15, 1993
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The clinical symptom complex characterized by syncopal attacks and sudden death in patients with electrocardiographic anomalies, especially a prolonged Q-t interval is known as the Romano-Ward syndrome. When a similar syptom complex is accompanied by congenital deafness, it is called Jervell and Lange-Nieisen syndrome. This study was underataken to investigate the incidence of the latter syndrome in the... |
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- Clinical Assessment of Neonatal Transient Tricuspid Insuffieciency - Doppler Echocardiographic Study-
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Se Geun Park, Dong Gun Park, Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1993;36(6):785-790. Published online June 15, 1993
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Eight neonates with transient tricuspid insufficiency are presented which was confirmed clinical and two dimensional echocardiographic assessment.
We found that two dimensional Doppler echocardiography was very useful in the detection of transient tricuspid insufficiency during neonatal age as noninvasive method.
Transient tricuspid insufficiency is a clinical disorder in the newborn period caused by myocardial dysfunction, secondary to asphyxia with or without... |
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- A Clinical Study on Febrile Convulsion
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Jung Hwan Lee, Ki Hwan Yoo, Yong Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1993;36(6):850-857. Published online June 15, 1993
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Although febrile convulsion(FC) is a common clinical entity with a high recurrence rate, no specific factors have been identified to be highly predictive of its recurrence.
A total to 114 cases of FC identified during a 28 month period (January, 1989-May, 1991) was analysed.
A silght predominance of boys over girls(1.3 to 1.0) was observed. The majority of cases(89.4%) were under 3... |
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- Obesity in Elementary School Children
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Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1993;36(3):338-346. Published online March 15, 1993
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Obesity has been implicated as a significant risk factor for multiple medical condition including hypertention, glucose intolerance, hyperlipidemia, hyperisulinemia and fatty liver. Furthermore, obesity in childhood is believed to be a reliable predictor of a similar condition in adulthood. During the recent yars, there has been a rapid rise in the incidence of childhood obesity in Korea due to increased... |
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- A Clinical Study on Early Diagnosis in Neonatal Sepsis
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Jong Kwang Lee, Hae Won Cheon, Jee Hee Park, Jung Hwa Lee, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1993;36(1):49-56. Published online January 15, 1993
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Neonatal sepsis is a major contributing factor for increased mortality and morbidity in the newborn and its successful outcome depends on early detection and prompt institution of an effective antimicrobial therapy. Accurate diagnosis of the neonatal septicemia, however, is quite difficult because its early signs and symptoms are rather subtle.
This study was conducted in an attempt to search for useful... |
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- Clinical Evaluation of Reactive Thrombocytosis in Childhood
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Yoon Suck Suh, Young Yoo, Kwang Chul Lee, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1992;35(5):607-613. Published online May 15, 1992
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The platelet coiunt has not been part of routine hematologic profiles until recently, when the newer electronic blood cell counters began to include platelet count with all other blood cell counts. With the widespread use of newer generation electronic blood cell counters, elevated platelets coiunts are being encountered more ofter in pediatric practice.
We reviewed all cases of marked thrombocytosis to... |
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- Case Report
- An Autopsy Case of Infant of Diabetic Mother with d-Transposition of Great Arteries and Hypertrophic Cardiomyopathy
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Kye Hwan Seol, Eui Kyeung Jung, Chang Sung Son, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1992;35(4):545-550. Published online April 15, 1992
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Generally, infants of diabetic mother(IDM) have various diseases and complications affecting multisystems resulting in high perinatal morbidity and mortality. It is well known that IDM have especially higher incidence of congenital anomalies including congenital heart disease(CH D). dTransposition of great arteries(d-TGA), ventricular septal defect and hypertrophic cardiomyopathy(HCM) form most of CHD occurring in IDM. Of these, HCM appears as a... |
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- Original Article
- The Effect of Prostaglandin E1 Infusion for Palliation of Ductus Dependent Cyanotic Congenital Heart Disease in Neonates
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Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1992;35(3):364-370. Published online March 15, 1992
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Prostaglandin E1 (PGE1) was administered to 12 neonates with cyanotic congenital heart disease in whom pulmonary or systemic blood flow were entirely or significantly dependent on persistent patency of the ductus arteriosus.
10 neonates responded favorably to PGE1, by showing significant increase of PaO2 after PGE1 infusion but remaining 2 neonates with hypoplastic left heart syndrome failed to respond. The... |
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- A Cause of Transient Systolic Murmur in Neonates Physiologic Pulmonary Artery Stenosis
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Hyun Joo Kwak, Phil Seob Sim, Kwang Chul Lee, Chang Sung Sohn, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1992;35(12):1696-1701. Published online December 15, 1992
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A transient heart murmur is frequently heard in normal newborn who has no congenital heart disease. The cause of this murmur remains unclear but was speculated as hypoplasia of the pulmonary arterial branches or unusual alignment of the main pulmonary artery with its branches.
Pulsed Doppler and two-dimensional echocardiographic studies were undertaken in 19 newborn infants with a transient murmur and... |
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- Pulsed doppler echocardiographic analysis of pulmonary venous flow in congenital heart diseases with left-to-right shunt.
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Kye Hwan Seol, Chang Sung Son, Joo Won Lee, Soon Kyum Kim, Young Chang Tockgo
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Clin Exp Pediatr. 1991;34(7):934-939. Published online July 31, 1991
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Pulsed Doppler echocardiography was performed to evaluate the flow velocity pattern of the
pulmonary vein in 28 patients with congenital heart diseases which comprised of 8 atrial septal defect
(ASD), 14 ventricular septal defect (VSD) and 6 patent ductus arteriosus (PDA). 20 normal children
served as controls. The objective of this study was to ascertain that pulmonary venous flow velocity
is dependent on the... |
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- Clinical study of supraventricular tachycardia in children.
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Eui Kyung Chung, Yun Seok Suh, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1991;34(6):796-804. Published online June 30, 1991
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Supraventricular tachycardia is the most symptomatic dysrhythmia encountered in infants and
children. Recognition of the dysrhythmias is of great clinical importance, since increasing number of
infants will develop congestive heart failure and occasionally circulatory collapse. Retrospective
study was done in 17 patients with supraventricular tachycardia, who were admitted to our hospital
from 1983 to 1989.
The results were as follows:
1) 47 percent of our patients with... |
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- Acute hemodynamic effects of increasing hemoglobin concentration in children with congenital heart disease and relative anemia.
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You In Park, Young You, Chang Sung Son, Joo Won Lee, Young Chang Tocko
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Clin Exp Pediatr. 1991;34(6):787-795. Published online June 30, 1991
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The short-term effects of increasing hemoglobin concentration were evaluated on cardiac catheter-
ization in nine patients with congenital heart diseases and relative anemia. Diagnosis were ventricular
septal defect in six, tetralogy of Fallot in two, and endocardial cushion defect in one. Various
hemodynamic data including pulmonary and systemic blood flow, pulmonary and systemic vascular
resistance and the degree of shunt were compared before and... |
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- Conjoined Thoracopagus Twins.
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Min Young Lee, Young Yoo, Ji Tae Choung, Joo Won Lee, Young Chang Tockgo, Yang Seouk Chae
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Clin Exp Pediatr. 1990;33(5):671-674. Published online May 31, 1990
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Conjoined twins are very rare congenital malformation in which twins have varying degree of
anatomical union. The conjoined twins seems preferable to such as craniopagus, thoracopagus,
ischiopagus and pyopagus. Because of their associated anomalies, particularly of cardiovascular
system, and difficulties in delivery, they usually survive only short postnatal period. Successful
surgical separation and long term survival would have been achieved in a small numbers... |
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- A case of Transient Tricuspid Insufficiency of Newborn(TTI).
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Young Kyoo Shin, Eui Kyung Jung, Sang Hee Kim, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1990;33(4):534-538. Published online April 30, 1990
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Transient Tricuspid Insufficiency(TTI) of newborn is a feature of myocardial dysfunction caused
by myocardial hypoxemia secondary to reduced arterial oxygen content and excessive right
ventricular work consequent to pulmonary hypertension.' Since Doppler echocardiography has been
used to diagnose cardiac disease, it allows recording of regurgitant turbulent flow pattern. We report
one case of TTI in a 36 week-gestational-aged newborn detected by continuous wave Dopplar
echocardiography... |
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- Changein Regional Cerebral Blood Flow Velocity in Premature Infant.
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Young Kyoo Shin, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1990;33(10):1333-1340. Published online October 31, 1990
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In order to estimate the influence of systemic hemodynamic change in cerebral blood flow before
and after closure of ductus arteriosus in premature mewborn infants, blood flow velocities of internal
carotid artery (ICA), anterior cerebral artery (ACA) and middle cerebral artery (MCA) were measured
in 17 premature newborn infants by pulsed Doppler ultrasonography. The data was compared with
those of normal full-term infants by... |
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- A Case of Double Outlet Left Ventricle with subaortic Ventricular Septal Defect and Pulmonary Atresia.
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Hea Kyoung Lee, Chang Sung Son, Joo Won Lee, Young Chang Tockgo, Pyung Wha Choi, In Sung Lee, Hyung Mook Kim
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Clin Exp Pediatr. 1988;31(6):784-789. Published online June 30, 1988
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Double outlet left ventricle is one of the rarest and least well understood congenital anomalies
the heart, with means that more than 1 l/2great arteries arise above the morphologically left
ventricle.
We experienced a case of double outlet left ventricle (S,L，L) with subaortic ventricular septal defect
and pulmonary atresia in a male neonate, which was diagnosed at autopsy.
A brief review of literature was made. |
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- Case Report
- A case of hypereosinophilic syndrome.
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Sung Hun Eun, Joo Won Lee, Se Jin Kang, Soon Kyum Kim
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Clin Exp Pediatr. 1985;28(9):922-925. Published online September 30, 1985
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Hypereosinophilic syndrome is a disorder characterized by peripheral blood & bone marrow eosinophilia associated with single or multiple organ system dysfunctions. The diagnostic criteria includes a peripheral blood eosinophilia of 1,500 eosinophils/cu mm for 6 Months or longer, signs and symtoms of organ involvement, and a lack of evidence for parasitic, allergic, or other known causes of eosinophilia. We have... |
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